Xanthan gum is modified to its carboxymethyl derivative which in turn can be used as sustained release delivery carrier as rate controlling polymer. The modified gum shows improved physical properties like good aqueous solubility, acceptable solution viscosity and clarity compared to the unmodified one. The reaction was carried out by using mono-chloroacetic acid and sodium hydroxide. Carboxymethylation was confirmed by fourier-transformed infra-red spectra. Metronidazole loaded polyelectrolyte complex was prepared by using carboxymethyl xanthan and chitosan. The resulting product was characterized by FTIR spectroscopy study. Polyelectrolyte complex was optimized with respect to concentration of carboxymethyl xanthan and chitosan.
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